Responsible DepartmentResearch PartnersResponsible DepartmentResearch PartnerThe Center of Medical Innovation and Translational ResearchThe Center of Medical Innovation and Translational ResearchImmunopharmaceutical Development Unit20206F6F 0613B0612The purpose of this project is to apply vaccine therapy as a next-generation biologics to the treatment of lifestyle-related diseases and intractable diseases, and to develop a basic technology for safer and more efficient therapeutic vaccines. This basic technology can be applied to the treatment of various diseases and has the potential to spread not only to developed countries but also to developing countries. To develop therapeutic vaccines for clinical application targeting the treatment of infectious diseases, lifestyle-related diseases, and intractable diseases and novel vaccine to deplete aging cells, AnGes Corporation, Daicel Corporation, and Funpep Corporation, together with the Department of Health Development and Medicine (Professor Nakagami), are collaborating in an industry-academic framework to develop a therapeutic vaccine, which will be originated in Japan. We will carry out translational research on therapeutic vaccines.We have demonstrated that immune cells localized in the skin are involved in the development, relapse and prognosis of skin diseases. In this collaborative research program, we aim to clarify the subtypes of skin immune cells, centering skin TRM, involved in cutaneous immune-mediated diseases, and to elucidate the key factors regulating the development and function of these cells. Our goal is to develop the therapeutic strategies targeting these factors.B-14A-30Department of Health evelopment and MedicineDepartment of DermatologyDepartment of Health evelopment and MedicineDepartment of Medicine for Cutaneous Immunological Diseases HAYASHI HirokiEndowed Chair Associate ProfessorWATANABE ReiGuest ProfessorNAKAGAMI HironoriEndowed Chair ProfessorFUJIMOTO ManabuProfessorDepartment of Health Development and MedicineDaicel CorporationFunPep Co., Ltd.Department of Medicine for Cutaneous Immunological Diseases Maruho Co., Ltd.Therapeutic Vaccines as Next Generation BiologicsElucidation of pathological mechanisms in cutaneous immune-mediated disorders and validation of therapeutic targets
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