＆Research and Development DepartmentThe Center of Medical Innovation and Translational ResearchResponsible DepartmentResearch PartnerResponsible DepartmentResearch Partner21217F7F07090713Rapid increase in dementia cases is becoming a serious social issue worldwide. Recent literature suggests that early diagnosis and interventions can prevent dementia progression or onset. This highlights the need for more efficient and convenient diagnostic tools to address the worldwide dementia epidemic. We developed a novel screening test for dementia using an eye-tracking technology (eye-tracking-based cognitive assessment, ETCA) and demonstrated its utility in clinical settings. We are going to further improve its performance and expand our project worldwide.We are focusing on the development of novel therapies using adipose-derived stem cells (ADSCs) with enhanced functions via gene transfer. The response to treatment of ischemic stroke by autologous mesenchymal stem cells, including ADSCs, varies widely among individuals. In particular, ADSCs from elderly individuals have been reported to have decreased expression of hepatocyte growth factor (HGF), decreased levels of exosome miRNAs that promote nerve regeneration, and increased expression of exosome miRNAs associated with inflammation and aging. By introducing various genes, including HGF, we aim to create ADSCs designed to restore these impaired functions, accumulate efficiently at the site of injury, and exert sufficient therapeutic effect, thereby becoming a breakthrough therapy for ischemic stroke and multiple sclerosis.B-16B-15Department of Clinical Gene TherapyDepartment of GeneStem ＆Cell Regenerative TherapyDepartment of Clinical Gene TherapyDepartment of Stem Gene＆Cell Regenerative TherapyMORISHITA RyuichiEndowed Chair ProfessorTAKEDA ShukoEndowed Chair Associate ProfessorSHIMAMURA MunehisaGuest ProfessorCHANG Chin-YangEndowed Chair Assistant ProfessorDepartment of Clinical Gene TherapyAi-BrainScience Inc.Department of GeneStem Cell Regenerative TherapyAS Medical Support Co., Ltd.Next-generation digital biomarker for early diagnosis of dementiaDevelopment of next-generation designer cell with improved adipose-derived stem cells (ADSCs)
元のページ ../index.html#22