Responsible DepartmentResearch PartnerResponsible DepartmentResearch Partner292907046F 0613A, 0911B7FOur skin, the largest organ in the human body, protects us from the outside world. It also contains a diverse range of microorganisms that can impact our health. In particular, dysbiosis, which disrupts the normal bacterial flora, is known to occur in diseases such as acne vulgaris, atopic dermatitis, and psoriasis. However, the precise mechanism by which skin microorganisms affect the host's health and diseases is not well understood, and elucidating this could lead to the development of new treatments and preventative measures for skin diseases. Our laboratory employs cutting-edge analytical methods for the skin microbiome and host immunity, as well as 3D skin devices created from induced pluripotent stem cells, to analyze various inflammatory skin diseases and reveal new disease mechanisms, while also working on controlling pre-disease states to achieve "healthy skin."In Japan, retinitis pigmentosa, diabetic retinopathy, and age-related macular degeneration, all of which affect the retina, account for more than 30% of the cause of visual impairment. While chronic inflammation deteriorates pathological condition in these retinal diseases, the molecular mechanisms regulating disease progression have not been fully elucidated. Our goal of the project is to develop novel therapies for resolving chronic inflammation. We attempt drug discovery approach under physiological conditions close to human organs using the animal model and organoid of specific eye diseases based on the research achievements of Ophthalmology at The University of Osaka.A-29A-6Immunology Frontier Research Center (IFReC)Department of DermatologyDepartment of OphthalmologyMATSUOKA YuumiProfessorFUJIMOTO ManabuProfessorNISHIDA KohjiProfessorDepartment of Cutaneous Immunology and MicrobiologyROHTO Pharmaceutical Co., Ltd.Department of Ocular Immunology and Regenerative MedicineOtsuka Pharmaceutical Co., Ltd.Research and Development DepartmentThe Center of Medical Innovation and Translational Research1. Understanding the pathogenesis of inflammatory skin diseases associated with dysbiosis2. Analysis of the impact of maintaining skin homeostasis on overall health spanElucidation of the involvement of chronic inflammation during the pathogenic processes of various ophthalmic diseases and the creation of treatments
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