Responsible DepartmentResearch PartnerResponsible DepartmentResearch Partners31318F8F 0813A, 08140812We found that some of necrotic tissue-derived factors induce mobilization of bone marrow mesenchymal stem/progenitor cells (MSCs) into the circulation if their concentration in the serum is highly elevated. This action results in the enhancement of tissue regeneration by increasing amount of circulating MSCs to the injured tissue. Goal of our project is to disclose the underlying molecular circuit of the injury-induced, MSC-mediated tissue regeneration mechanism in vivo. These findings will be applied to develop a novel medication to induce tissue regeneration by increasing MSCs’ circulation from the bone marrow to the tissues with intractable injury.We pursued research and development of the critical characteristics such as cancer stemness by building a biological diagnosis and drug discovery/development platform that is unparalleled in the world and based on integrated cutting-edge knowledge. We aim to accumulate multidimensional networking information, knowledge, and applications to develop and demonstrate the highest degree of academic flexibility. We plan to contribute to the industry and community by discovering biological diagnosis and drug discovery/development, and building highly accurate human models that precisely reflect the response of cancer stem cells to anticancer agents and patients’ pathologies, innovative metabolism analysis of cancer stem cells, trans-omics analysis, and highly accurate predictive molecular markers. These plans include, but are not limited to, companion drug development, next-generation nucleic acid drug development, innovative drug delivery systems, and the redevelopment of discontinued drugs.A-7B-6Department of Stem Cell Therapy ScienceDepartment of Medical Data ScienceDepartment of Stem Cell Therapy ScienceTAMAI KatsutoGuest ProfessorSAGA KotaroEndowed Chair Associate ProfessorISHII HideshiSpecially Appointed ProfessorDepartment of Stem Cell Therapy ScienceStemRIM Inc.Department of Medical Data ScienceSUMITOMO CHEMICAL COMPANY, LIMITEDHirotsu Bio Science Inc.IDEA Consultants Inc.Unitech Co. Ltd.Research and Development DepartmentThe Center of Medical Innovation and Translational ResearchDevelopment of novel medicine for inducing scarless and functional tissue regeneration by mobilizing bone marrow mesenchymal stem cellsEstablishing cancer profiling to develop innovative, personalized medicine and therapeutics
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