Elucidation of the involvement of chronic inflammation during the pathogenic processes of various ophthalmic diseases and the creation of treatments

In Japan, retinitis pigmentosa, diabetic retinopathy, and age-related macular degeneration, all of which affect the retina, account for more than 30% of the cause of visual impairment. While chronic inflammation deteriorates pathological condition in these retinal diseases, the molecular mechanisms regulating disease progression have not been fully elucidated. Our goal of the project is to develop novel therapies for resolving chronic inflammation. We attempt drug discovery approach under physiological conditions close to human organs using the animal model and organoid of specific eye diseases based on the research achievements of Ophthalmology at Osaka University.