Analysis of the functions of pathological or physiological periostin

"Alternative splicing variant (ASV)," a mechanism in which multiple products are produced from a single gene by variant switch, not only enables the acquisition of complex morphology and cellular functions of multicellular organisms but is also deeply involved in the pathogenesis of several diseases.
The purpose of this research is to selectively inhibit only ASV that is involved in the pathogenesis of chronic diseases such as cancer, heart failure, arteriosclerosis, renal failure, and diabetic retinopathy without inhibiting physiological ASV. We think that a safe and efficient therapy can be provided by selective inhibition of ASV. In this course, we will analyze the molecular mechanisms of pathological and physiological periostin and its in vivo functions such as transport of periostin mutants via exosomes or not.