1. Understanding the pathogenesis of inflammatory skin diseases associated with dysbiosis
2. Analysis of the impact of maintaining skin homeostasis on overall health span

Our skin, the largest organ in the human body, protects us from the outside world. It also contains a diverse range of microorganisms that can impact our health. In particular, dysbiosis, which disrupts the normal bacterial flora, is known to occur in diseases such as acne vulgaris, atopic dermatitis, and psoriasis. However, the precise mechanism by which skin microorganisms affect the host's health and diseases is not well understood, and elucidating this could lead to the development of new treatments and preventative measures for skin diseases. Our laboratory employs cutting-edge analytical methods for the skin microbiome and host immunity, as well as 3D skin devices created from induced pluripotent stem cells, to analyze various inflammatory skin diseases and reveal new disease mechanisms, while also working on controlling pre-disease states to achieve "healthy skin."

Principal Investigator