Elucidation of disease mechanisms and therapeutic targets in cutaneous immune-mediated disorders from the perspective of resident memory T cells

We have demonstrated that immune cells localized in the skin are involved in the development, relapse and prognosis of skin diseases. In this collaborative research program, we aim to clarify the subtypes of skin immune cells, centering skin TRM, involved in cutaneous immune-mediated diseases, and to elucidate the key factors regulating the development and function of these cells. Our goal is to develop the therapeutic strategies targeting these factors.